diff --git a/packages/flutter_tools/lib/src/ios/mac.dart b/packages/flutter_tools/lib/src/ios/mac.dart
index 200120f8dde..d61c40d1e50 100644
--- a/packages/flutter_tools/lib/src/ios/mac.dart
+++ b/packages/flutter_tools/lib/src/ios/mac.dart
@@ -918,6 +918,12 @@ _XCResultIssueHandlingResult _handleXCResultIssue({
         missingModule: missingModule,
       );
     }
+  } else if (message.toLowerCase().contains('has been modified since')) {
+    return _XCResultIssueHandlingResult(
+      requiresProvisioningProfile: false,
+      hasProvisioningProfileIssue: false,
+      modifiedPrecompiledSource: true,
+    );
   }
   return _XCResultIssueHandlingResult(
     requiresProvisioningProfile: false,
@@ -937,6 +943,7 @@ Future<bool> _handleIssues(
   var requiresProvisioningProfile = false;
   var hasProvisioningProfileIssue = false;
   var issueDetected = false;
+  var modifiedPrecompiledSource = false;
   String? missingPlatform;
   final duplicateModules = <String>[];
   final missingModules = <String>[];
@@ -962,6 +969,7 @@ Future<bool> _handleIssues(
       if (handlingResult.missingModule != null) {
         missingModules.add(handlingResult.missingModule!);
       }
+      modifiedPrecompiledSource = handlingResult.modifiedPrecompiledSource;
       issueDetected = true;
     }
   } else if (xcResult != null) {
@@ -1032,6 +1040,13 @@ Future<bool> _handleIssues(
         );
       }
     }
+  } else if (modifiedPrecompiledSource) {
+    logger.printError(
+      '════════════════════════════════════════════════════════════════════════════════\n'
+      'A precompiled file has been changed since last built. Please run "flutter clean" to clear '
+      'the cache.\n'
+      '════════════════════════════════════════════════════════════════════════════════',
+    );
   }
   return issueDetected;
 }
@@ -1169,6 +1184,7 @@ class _XCResultIssueHandlingResult {
     this.missingPlatform,
     this.duplicateModule,
     this.missingModule,
+    this.modifiedPrecompiledSource = false,
   });
 
   /// An issue indicates that user didn't provide the provisioning profile.
@@ -1186,6 +1202,10 @@ class _XCResultIssueHandlingResult {
   /// An issue indicates a module was imported but not found, potentially due
   /// to it being Swift Package Manager compatible only.
   final String? missingModule;
+
+  /// An issue indicates that a source file, such as a header in the Flutter framework, has
+  /// changed since last built. This requires "flutter clean" to resolve.
+  final bool modifiedPrecompiledSource;
 }
 
 const _kResultBundlePath = 'temporary_xcresult_bundle';
diff --git a/packages/flutter_tools/test/general.shard/ios/mac_test.dart b/packages/flutter_tools/test/general.shard/ios/mac_test.dart
index b1598f53723..12a2aed2a5f 100644
--- a/packages/flutter_tools/test/general.shard/ios/mac_test.dart
+++ b/packages/flutter_tools/test/general.shard/ios/mac_test.dart
@@ -670,6 +670,56 @@ duplicate symbol '_$s29plugin_1_name23PluginNamePluginC9setDouble3key5valueySS_S
         Pub: ThrowingPub.new,
       },
     );
+
+    testWithoutContext('parses file has been modified error', () async {
+      const buildCommands = <String>['xcrun', 'cc', 'blah'];
+      final buildResult = XcodeBuildResult(
+        success: false,
+        stdout: '',
+        xcodeBuildExecution: XcodeBuildExecution(
+          buildCommands: buildCommands,
+          appDirectory: '/blah/blah',
+          environmentType: EnvironmentType.physical,
+          buildSettings: buildSettings,
+        ),
+        xcResult: XCResult.test(
+          issues: <XCResultIssue>[
+            XCResultIssue.test(
+              message:
+                  "File 'path/to/Flutter.framework/Headers/FlutterPlugin.h' has been modified since "
+                  "the precompiled header 'path/to/Runner.build/Objects-normal/arm64/Runner-primary-Bridging-header.pch'"
+                  ' was built: size changed (was 18306, now 16886)',
+              subType: 'Error',
+            ),
+            XCResultIssue.test(
+              message:
+                  "File 'path/to/Flutter.framework/Headers/FlutterEngine.h' has been modified since "
+                  "the precompiled header 'path/to/Runner.build/Objects-normal/arm64/Runner-primary-Bridging-header.pch'"
+                  ' was built: size changed (was 18306, now 16886)',
+              subType: 'Error',
+            ),
+          ],
+        ),
+      );
+      final fs = MemoryFileSystem.test();
+      final project = FakeFlutterProject(fileSystem: fs, usesSwiftPackageManager: true);
+      project.ios.podfile.createSync(recursive: true);
+      await diagnoseXcodeBuildFailure(
+        buildResult,
+        logger: logger,
+        analytics: fakeAnalytics,
+        fileSystem: fs,
+        platform: FlutterDarwinPlatform.ios,
+        project: project,
+      );
+      expect(
+        logger.errorText,
+        contains(
+          'A precompiled file has been changed since last built. Please run "flutter clean" to '
+          'clear the cache.',
+        ),
+      );
+    });
   });
 
   group('Upgrades project.pbxproj for old asset usage', () {