diff --git a/packages/flutter_tools/lib/src/build_system/targets/dart_plugin_registrant.dart b/packages/flutter_tools/lib/src/build_system/targets/dart_plugin_registrant.dart
index 497b4c0303a..d5f2fb0e869 100644
--- a/packages/flutter_tools/lib/src/build_system/targets/dart_plugin_registrant.dart
+++ b/packages/flutter_tools/lib/src/build_system/targets/dart_plugin_registrant.dart
@@ -66,6 +66,8 @@ class DartPluginRegistrantTarget extends Target {
     // TODO(stuartmorgan): Investigate removing this check entirely; ideally the
     // source generation step shouldn't be platform dependent, and the generated
     // code should just do the right thing on every platform.
+    // Failing that, consider throwing if `targetPlatform` isn't set and finding
+    // all violations, as it's not consistently set here.
     return targetPlatform == TargetPlatform.fuchsia_arm64 ||
            targetPlatform == TargetPlatform.fuchsia_x64 ||
            targetPlatform == TargetPlatform.web_javascript;
diff --git a/packages/flutter_tools/lib/src/isolated/resident_web_runner.dart b/packages/flutter_tools/lib/src/isolated/resident_web_runner.dart
index c80a58d2a8d..41d5f6266d9 100644
--- a/packages/flutter_tools/lib/src/isolated/resident_web_runner.dart
+++ b/packages/flutter_tools/lib/src/isolated/resident_web_runner.dart
@@ -145,6 +145,10 @@ class ResidentWebRunner extends ResidentRunner {
   @override
   bool get supportsWriteSkSL => false;
 
+  @override
+  // Web uses a different plugin registry.
+  bool get generateDartPluginRegistry => false;
+
   bool get _enableDwds => debuggingEnabled;
 
   ConnectionResult _connectionResult;
diff --git a/packages/flutter_tools/lib/src/resident_runner.dart b/packages/flutter_tools/lib/src/resident_runner.dart
index bbe3ecc0994..e59cd5527db 100644
--- a/packages/flutter_tools/lib/src/resident_runner.dart
+++ b/packages/flutter_tools/lib/src/resident_runner.dart
@@ -1101,6 +1101,10 @@ abstract class ResidentRunner extends ResidentHandlers {
 
   bool get trackWidgetCreation => debuggingOptions.buildInfo.trackWidgetCreation;
 
+  /// True if the shared Dart plugin registry (which is different than the one
+  /// used for web) should be generated during source generation.
+  bool get generateDartPluginRegistry => true;
+
   // Returns the Uri of the first connected device for mobile,
   // and only connected device for web.
   //
@@ -1152,7 +1156,7 @@ abstract class ResidentRunner extends ResidentHandlers {
       processManager: globals.processManager,
       platform: globals.platform,
       projectDir: globals.fs.currentDirectory,
-      generateDartPluginRegistry: true,
+      generateDartPluginRegistry: generateDartPluginRegistry,
     );
 
     final CompositeTarget compositeTarget = CompositeTarget(<Target>[
diff --git a/packages/flutter_tools/test/general.shard/resident_web_runner_test.dart b/packages/flutter_tools/test/general.shard/resident_web_runner_test.dart
index 483ea0ae18b..ddb81efa4e7 100644
--- a/packages/flutter_tools/test/general.shard/resident_web_runner_test.dart
+++ b/packages/flutter_tools/test/general.shard/resident_web_runner_test.dart
@@ -941,6 +941,47 @@ void main() {
     ProcessManager: () => processManager,
   });
 
+  // While this file should be ignored on web, generating it here will cause a
+  // perf regression in hot restart.
+  testUsingContext('Does not generate generated_main.dart', () async {
+    // Create necessary files for [DartPluginRegistrantTarget]
+    final File packageConfig = globals.fs.directory('.dart_tool')
+        .childFile('package_config.json');
+    packageConfig.createSync(recursive: true);
+    packageConfig.writeAsStringSync('''
+{
+  "configVersion": 2,
+  "packages": [
+    {
+      "name": "path_provider_linux",
+      "rootUri": "../../../path_provider_linux",
+      "packageUri": "lib/",
+      "languageVersion": "2.12"
+    }
+  ]
+}
+''');
+    // Start with a generated_main.dart file.
+    globals.fs.directory('.dart_tool')
+              .childDirectory('flutter_build')
+              .childFile('generated_main.dart')
+              .createSync(recursive: true);
+
+    final FlutterProject project = FlutterProject.fromDirectoryTest(fileSystem.currentDirectory);
+
+    final ResidentRunner residentWebRunner = setUpResidentRunner(flutterDevice);
+    await residentWebRunner.runSourceGenerators();
+
+    // generated_main.dart should be untouched, indicating that its
+    // generation didn't run. If it had run, the file would have been removed as
+    // there are no plugins in the project.
+    expect(project.dartPluginRegistrant.existsSync(), true);
+    expect(project.dartPluginRegistrant.readAsStringSync(), '');
+  }, overrides: <Type, Generator>{
+    FileSystem: () => fileSystem,
+    ProcessManager: () => processManager,
+  });
+
   testUsingContext('Successfully turns WebSocketException into ToolExit', () async {
     final BufferLogger logger = BufferLogger.test();
     final ResidentRunner residentWebRunner = setUpResidentRunner(flutterDevice, logger: logger);