diff --git a/.bazelrc b/.bazelrc
index 59f854dc8..2ee414f72 100644
--- a/.bazelrc
+++ b/.bazelrc
@@ -188,6 +188,12 @@ build:apple-toolchain --apple_crosstool_top=@local_config_apple_cc//:toolchain
 build:apple-toolchain --crosstool_top=@local_config_apple_cc//:toolchain
 build:apple-toolchain --host_crosstool_top=@local_config_apple_cc//:toolchain
 
+# Wheel builds need the LiteRT runtime dylib linked into python extensions.
+# This config overrides the macos default above.
+build:macos_wheel --config=macos
+build:macos_wheel --define=resolve_symbols_in_exec=false
+build:macos_wheel --define=litert_macos_wheel_use_so=true
+
 # Settings for MacOS on ARM CPUs.
 build:macos_arm64 --config=macos
 build:macos_arm64 --cpu=darwin_arm64
diff --git a/ci/build_pip_package_with_bazel.sh b/ci/build_pip_package_with_bazel.sh
index 1106af854..36c5cbf90 100755
--- a/ci/build_pip_package_with_bazel.sh
+++ b/ci/build_pip_package_with_bazel.sh
@@ -19,6 +19,7 @@ set -ex
 export TF_LOCAL_SOURCE_PATH=${TF_LOCAL_SOURCE_PATH:-"$(pwd)/third_party/tensorflow"}
 
 ARCH="$(uname -m)"
+OS_NAME="$(uname -s)"
 TENSORFLOW_TARGET=${TENSORFLOW_TARGET:-$1}
 if [ "${TENSORFLOW_TARGET}" = "rpi" ]; then
   export TENSORFLOW_TARGET="armhf"
@@ -59,6 +60,11 @@ case "${TENSORFLOW_TARGET}" in
     ;;
 esac
 
+if [[ "${OS_NAME}" == "Darwin" ]]; then
+  # Ensure LiteRT runtime dylib is built and linked for macOS wheels.
+  BAZEL_FLAGS="${BAZEL_FLAGS} --config=macos_wheel"
+fi
+
 if [[ -n "${BAZEL_CONFIG_FLAGS}" ]]; then
   BAZEL_FLAGS="${BAZEL_FLAGS} ${BAZEL_CONFIG_FLAGS}"
 fi
diff --git a/litert/c/BUILD b/litert/c/BUILD
index 624b040dd..20bbfb597 100644
--- a/litert/c/BUILD
+++ b/litert/c/BUILD
@@ -650,7 +650,11 @@ cc_test(
 # TODO: b/437381008
 cc_library(
     name = "litert_runtime_c_api_so_shim",
-    linkopts = ["-Wl,--undefined-glob=LiteRt*"],
+    linkopts = select({
+        "@platforms//os:macos": [],
+        "@platforms//os:ios": [],
+        "//conditions:default": ["-Wl,--undefined-glob=LiteRt*"],
+    }),
     deps = LITERT_C_API_COMMON_DEPS,
 )
 
@@ -659,9 +663,10 @@ cc_shared_library(
     name = "litert_runtime_c_api_so",
     additional_linker_inputs = export_lrt_runtime_only_script(),
     shared_lib_name = "libLiteRt.so",
-    user_link_flags = export_lrt_runtime_only_linkopt() + [
-        "-Wl,-soname=libLiteRt.so",
-    ] + litert_android_linkopts(),
+    user_link_flags = export_lrt_runtime_only_linkopt() + select({
+        "@platforms//os:macos": ["-Wl,-install_name,@rpath/libLiteRt.so"],
+        "//conditions:default": ["-Wl,-soname=libLiteRt.so"],
+    }) + litert_android_linkopts(),
     deps = [":litert_runtime_c_api_so_shim"],
 )
 
@@ -747,7 +752,11 @@ exports_files(srcs = ["windows_exported_symbols.def"])
 # TODO: b/437381008
 cc_library(
     name = "litert_tflite_runtime_c_api_so_shim",
-    linkopts = ["-Wl,--undefined-glob=LiteRt*"],
+    linkopts = select({
+        "@platforms//os:macos": [],
+        "@platforms//os:ios": [],
+        "//conditions:default": ["-Wl,--undefined-glob=LiteRt*"],
+    }),
     deps = LITERT_C_API_COMMON_DEPS + [
         "//tflite/c:c_api",
         "//tflite/c:c_api_experimental",
@@ -771,7 +780,8 @@ cc_shared_library(
 SELECT_LITERT_RUNTIME_C_API_SO = select({
     ":resolve_symbols_in_exec": [],
     "@platforms//os:ios": [":litert_runtime_c_api_dylib"],
-    "@platforms//os:macos": [":litert_runtime_c_api_dylib"],
+    ":litert_macos_wheel_use_so": [":litert_runtime_c_api_so"],
+    ":litert_macos_default": [":litert_runtime_c_api_dylib"],
     "@platforms//os:windows": [],
     "//conditions:default": [":litert_runtime_c_api_so"],
 })
@@ -790,6 +800,18 @@ config_setting(
     define_values = {"resolve_symbols_in_exec": "true"},
 )
 
+config_setting(
+    name = "litert_macos_wheel_use_so",
+    constraint_values = ["@platforms//os:macos"],
+    define_values = {"litert_macos_wheel_use_so": "true"},
+)
+
+config_setting(
+    name = "litert_macos_default",
+    constraint_values = ["@platforms//os:macos"],
+    define_values = {"litert_macos_wheel_use_so": "false"},
+)
+
 filegroup(
     name = "c_api_headers",
     srcs = glob(["litert_*.h"]),